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The role of R-2-HG as an oncometabolite has been implicated in epigenetic modifications through the inhibition of -KG-dependent dioxygenases and demethylases, which has been assumed to be a driver of tumorigenesis 117,118
This is because L-Carnitine plays a critical role in energy production and muscle recovery, processes that are intensified with vigorous exercise
However, its application in topical formulations is severely hindered by its rapid oxidation, intrinsic instability, and poor permeability across the stratum corneum
10.1016/j.bbamem.2015.12.026 Biochim
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