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The breakdown happens in tissues through normal metabolic pathways, not in a single organ, which is why clearance takes time

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Its formula relies on a combination of two luminance-boosting additives: tranexamic acid, and antioxidant niacinamide (also known as vitamin B3)

As each dataset has multiple experimental groups, to correct for the variance between studies while preserving variance between cell types and experimental groups, we trained the single-cell variational inference (scVI) model 55 on the control groups from each study with the study as the batch key, and then integrated the experimental groups (Extended Data Fig

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