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Semaglutide is a medication that may be prescribed by a licensed healthcare provider as part of a medically supervised weight management program
Tirzepatide gained an obstructive sleep apnea indication supported by the SURMOUNT-OSA program (NEJM, 2024), distinguishing it from products indicated only for glucose control or weight management
Unanswered questions and future directions A potential explanation for the fact that pharmacologically administered GLP-1 analogues show acute neuroprotective efficacy in the rodent while endogenous GLP-1 levels do not correlate with stroke recovery in patients could be that treatment with pharmacological agents in rodents are often given in higher doses
Note that the 0.25 mg, 0.5 mg, and 1 mg doses of injectable semaglutide for weight management are starting doses and do not result in significant weight loss
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