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As a small molecule, orforglipron naturally survives digestion, absorbs efficiently through the gut, and achieves predictable blood levels without absorption enhancers or special dosing protocols
TZDs uniquely target insulin resistance, which is a core physiologic defect in T2D, and significantly improve glucose control
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& Miller, J
Increasing evidence indicates that high mobility group box 1 (HMGB1), a nuclear protein released from dendritic cells, macrophages, and necrotic cells during inflammation, plays an important pathological role in DKD by activating TLR2 and TLR4 signaling (195)
