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Neither medication is licensed for weight loss in the UK
[1] Dose-dependent effects are evident, with higher doses of semaglutide (7mg and 14mg) associated with increased frequency and severity of gastrointestinal symptoms compared to the 3mg starting dose
This pharmacokinetic profile provides a natural taper period, though patients should understand that appetite suppression and glycemic benefits will progressively decline during this window
Non-oral methods are not affected
10.1152/japplphysiol.00945.2010 12 ChronopoulosA.SchutzJ
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