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Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions

The human doses were converted to mouse-equivalent doses using a standard adult human body weight of 60 kg, resulting in the following dosages: 0.00166 g/kg/day for glutathione, 0.00666 g/kg/day for Ganoderma lucidum extract, and 0.00666 g/kg/day for vitamin C

Inhibition or depletion of GPX4 utilizing the chemical inhibitor RSL3 or specific siRNA resulted in lipid peroxide accumulation, leading to ferroptosis in H9C2 cells [87]

Oral route glutathione technically covers two different options: sublingual and swallowed

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