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Tolerability All the participants went through short-term modified fasting without hypoglycemia or other severe adverse reactions

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Shifting by four or five days disrupts the steady state and may increase breakthrough symptoms between doses

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This framework generates testable predictions and potential monitoring endpointsincluding lean mass trajectory, micronutrient status, fat-soluble vitamin surveillance, and exploratory redox-related biomarkersthat can be evaluated in future longitudinal and interventional studies