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Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]
Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions
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Pain 138:318329 Al-Khrasani M, Lack E, Riba P, Kirly K, Sobor M, Timr J, Mousa S, Schfer M et al (2012) The central versus peripheral antinociceptive effects of -opioid receptor agonists in the new model of rat visceral pain
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