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Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases

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Vitamin B 12 is needed to produce an adequate amount of healthy red blood cells in the bone marrow

A large cardiovascular outcomes trial is ongoing and expected to provide important long-term safety insights, with results anticipated around 2027