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47,48 Glucosidases I and II in the ER progressively remove glucose residues from the N -glycans of newly synthesized glycoproteins to generate Glc 1 Man 9 GlcNAc 2 , which is detected by the calnexin/calreticulin cycle and serves as a signal to promote glycoprotein folding

The benefit appeared more pronounced in men with mild to moderate ED and in those with documented endothelial dysfunction or low baseline NO levels