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Side Effects of Each Medication Both medications can cause specific side effects, and understanding these side effects can help you make an informed decision: Common Side Effects for Both Nausea (most common, especially when starting) Vomiting Diarrhea Constipation Stomach pain Fatigue Headache Semaglutide-Specific Side Effects Nausea affects about 44% of users initially Side effects typically improve after 4-8 weeks Injection site reactions are rare Tirzepatide-Specific Side Effects Nausea affects about 12-18% of users (lower than Semaglutide) May cause more digestive upset initially Some patients report better tolerance overall Most side effects are temporary and resolve as your body adjusts to the medication
When fat stores diminish rapidly, leptin levels fall, which can disrupt the pulsatile release of gonadotrophin-releasing hormone (GnRH) from the hypothalamus
It converts food into usable energy and prevents fatigue when taking a low-calorie diet
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