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doi:10.1016/j.cnr.2004.09.013
This is one of the most common reasons patients transition between these medications
Comment Period and What Happens Next The Federal Register notice public comment period extends through June 30, 2026
Ten trials 13,14,2632 had sufficient data for the meta-analysis (n=366 treatment, n=359 control), and five trials 15,26,3335 were excluded from quantitative synthesis due to incomplete or non-extractable data
Older appetite suppressants (stimulant-based) worked through the nervous system and often lost effectiveness over weeks or months as the body adapted
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