Importance of Ca 2+ , K + and glucose in the medium for sperm penetration through the human zona pellucida
They are formed during the Maillard reaction, when sugars and amino acids combine at high temperatures and low water activity
Ward and Heel, 1984
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Although epigenetic regulatory mechanisms have been confirmed as key intervention links, relevant research is still weak, and it is necessary to strengthen studies on the role of non-coding RNAs such as circRNA, lncRNA, and miRNA, as well as DNA/histone modifications in mediating the effects of natural products (Provencher et al., 2018