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The new 5-HT hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

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[11] Serious but uncommon events include immediate-type hypersensitivity with urticaria, bronchospasm, or anaphylaxis, and delayed eosinophilic myositis