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doi: 10.1038/s41585-023-00768-5 52 FryerMJ

Serum melatonin levels in psoriasis and associated depressive symptoms

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showed that SCO alone reduced the expression of apoptosis-associated speck-like protein containing a CARD (ASC), IL-1, TNF- and IL-6, inhibited the activation of NLRP3 inflammasome in the liver, and increased the levels of the antioxidants CAT and SOD, thus ameliorating liver inflammation (33)

some peptide-industry sources report a Pharmacy Compounding Advisory Committee review was scheduled for July 2026 that could revisit this status, but that outcome had not been independently confirmed as of this writing