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Following a [14C]sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin
ROS-mediated oxidative stress promotes mitochondrial dysfunction, fostering a self-reinforcing cycle where increased ROS generation perpetuates lipids, proteins and DNA oxidation, thereby exacerbating cellular injury [231]
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Therefore, TLRs can act as novel vaccines against allergic asthma
and into the roles that melanocytes and melanin play in the maintenance of homeostasis of the oral mucosa, as well as into the roles physiological or benign oral mucosal melanin hyperpigmentations may play as precursors of premalignant and malignant oral melanotic lesions
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