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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

Temperature excursions above 8C accelerate this timeline even brief exposure to room temperature (25C) for 24 hours reduces stability to 14 days or less

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Personalized dosing plan 3

Trotta F et al