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Cholinergic hypothesis states that the degeneration of basal forebrain neurons in AD patients leads to dysfunction and death of cholinergic neurons in the forebrain, followed by extensive presynaptic denervation occurs, and the loss of specific subtypes of acetylcholine receptors, leading to cognitive decline in AD patients (39)
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doi: 10.1152/ajpendo.1982.242.3.E206 87 ZieglerRBellwinkelSSchmidtchenDMinneH
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