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The strongest rationale for the oral route is local action in the digestive tract itself

dosing adjustments may be needed Delayed gastric emptying: may affect the absorption of oral meds and peri-anesthesia aspiration riskpatients should let their doctor know they are taking Mounjaro (or any GLP-1) prior to anesthesia-requiring procedures Diabetic retinopathy: can acutely worsen with rapid glycemic improvement in those with T2Dconsider baseline/ongoing eye care While these risks are low, your provider will weigh them against the benefits before prescribing

The Phase 3 STOP-MD3 randomized controlled trial evaluated oral SPI-1005 against a placebo over a 4-week dosing period, with secondary follow-up endpoints measured at 12 weeks

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Because semaglutide affects metabolism and digestion, it may also have an indirect effect on cortisol