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Its molecular structure differs somewhat from that of natural GLP-1 to increase its stability and longevity, hence boosting its therapeutic efficacy in weight control settings and beyond [3, 4]
Liver enzymes, markers of glycemic control, markers of insulin resistance and advanced biomarkers help to reveal the pathophysiology of MASLD and its progression to T2DM (106)
The same group showed that GLP-1 continued to suppress lipogenesis and increase lipolysis in day 14 differentiated cells from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), with the effects being more pronounced in SAT [31]
Third, immortal time bias may artificially inflate apparent protective effects if the period between cohort entry and treatment initiation is misclassified as exposed time
The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation
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