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To test the possibility that Ex-4c may inhibit K ATP channels to activate POMC neurons, we pretreated the slices with 200 M tolbutamide, a K ATP channel blocker, and found that five of 12 cells (41.7%) were depolarized by 3.90.5 mV (from 48.01.7 to 44.11.4 mV, n =5) (Fig

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Understanding how dietary choices influence your body's GLP-1 secretion provides an evidence-based approach to supporting metabolic health, though the effects differ substantially from prescription medications