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Additionally, some individuals taking Mounjaro may have pre-existing conditions that independently increase their risk of B12 deficiency, such as previous bariatric surgery or concurrent metformin use (the MHRA has highlighted that metformin can reduce vitamin B12 levels)

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Montero-Moran, G

Levels run high in young tissue and fall by more than half after age 60, which lines up with the slower healing and thinner skin people start to notice as the years stack up

Susceptibility [to absorbing the nutrient] varies, so if you take B6 supplements, you really should have a medical professional check your blood levels to make sure theyre not in excess. A peer-reviewed article provides more information about toxicity