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Wortmannin, a PI3K inhibitor, was unable to suppress RSL3 mediated cell death in RAS and TERT -expressing cells 26

Notably, supplementing glutamine in the tumor microenvironment led to a slowdown in tumor growth and restored T cell infiltration, function, and memory phenotype [152]

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Distinct from classical GH signaling (experimental): Research suggests minimal stimulation of IGF-1 and limited activation of pathways typically driven by full-length growth hormone

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