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Table of Contents What Retatrutide and Tesamorelin Do in the Body Potential Risks of Combining These Two Medicines What the Current Evidence Says About This Combination UK Prescribing Context and Regulatory Status When to Speak to a Doctor or Specialist Clinician Safer Alternatives and Evidence-Based Treatment Options Scientific References Frequently Asked Questions What Retatrutide and Tesamorelin Do in the Body Retatrutide activates GLP-1, GIP, and glucagon receptors to reduce body weight, whilst tesamorelin stimulates pituitary GH release to preferentially reduce visceral fat via entirely distinct physiological pathways

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The model's performance was also examined in a separate sample of 2,252 Scottish people, 1,837, and 415 started SGLT2i and GLP1-RA, respectively

Contraindications for GLP1 receptor agonist use include pancreatitis and history of medullary thyroid cancer