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The leap from that signal to a direct, measurable difference in MRI-quantified brain atrophy has not yet been demonstrated in a clean randomized trial, which is precisely the gap TAG-MS is designed to close

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Fan Ding, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers