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Description

SpragueDawley rats (~ 250 g) were anesthetized by intraperitoneal injection of Beuthanasia-D (38 mg pentobarbital sodium and 6 mg phenytoin sodium/230 g rat) (Schering-Plough Animal Health Corp., Union, NJ)

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They are well-tolerated but their ability to lower blood sugar is modest and they generally do not cause weight loss

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