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For patients with severe hypertriglyceridemia (500 mg/dL), dedicated triglyceride-lowering therapy and specialist referral should be considered regardless of tirzepatide use

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Severe, persistent abdominal pain also needs prompt evaluation

Earlier fullness during meals, leading to naturally smaller portions

Studies have shown that colorectal cancer liver metastasis (CRLM) PDOs can highly preserve the histopathological and molecular characteristics of primary tumors while successfully capturing intra- and inter-patient heterogeneity [180]