Simultaneously, NNMT inhibition preserves SAM the primary methyl-donor for epigenetic histone and DNA methylation reactions which has been shown to influence gene expression programmes governing adipogenesis, lipid storage, and energy expenditure in adipose tissue models
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This is because abdominal fat accumulation is often influenced by a combination of factors: Insulin resistance Hormonal changes Thyroid dysfunction Reduced muscle mass Chronic stress Poor sleep quality Inflammation Sedentary work patterns When several of these factors overlap, losing visceral fat becomes considerably more difficult than losing a few kilograms through short-term dieting