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[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration
Apparently, metformin acts directly on gut bacteria to increase their vitamin B12 uptake, leading to increasing competition for available dietary vitamin B12 and ultimately to human vitamin B12 deficiency (55)
Phentermine belongs to the drug class called CNS stimulants
ARA 290 stands out because it has accumulated meaningful human clinical evidence while remaining relatively unknown
Because of this, the location often has less impact on effectiveness than many people assume
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