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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization

The later stages of the dosages for these types of vitamin B12 therapy will be planned according to the test results

The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions

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B12 supports mitochondrial function and cellular energy production through its role in fatty acid oxidation and the citric acid cycle