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The most widely prescribed GLP-1 for weight loss

While GLP-1 agonists have become a staple for weight loss and type 2 diabetes management, those with type 1 diabetes taking these medications off-label should be mindful of possible adverse effects, including hypoglycemia and diabetic ketoacidosis (DKA), a serious complication resulting from a lack of insulin in the body

GLP-1 medications work by quieting hunger signals in your brain and slowing digestion, which is exactly why so many patients lose weight

Moreover, GLP-1RAs can reverse EndMT induced by high glucose and IL-1 via activating the AMPK pathway, which was evidenced by augmenting an endothelium marker expression (CD31), as well as alleviating mesenchymal markers expression (SM22 (sensitive 22 kDa actin-binding protein of the calponin), vimentin and Snail) [119]

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