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Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

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Low serotonin levels reduce impulse control, making it harder to resist the immediate gratification that dopamine-driven rewardslike substances or addictive behaviorsprovide

Barriers to Access and Adherence: Only 1 in 10 Receives MAT Why do only about 1 in 10 people with OUD get MAT