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GLP-1s slow the process of gastric emptyingfood leaving the stomach
Importantly, the FDA labeling cautions against using semaglutide in patients with severe gastrointestinal disease, including severe gastroparesis
Shaking the vial introduces aggressive mechanical stress that can denature the delicate peptide chains, rendering the retatrutide ineffective
[6] [7] These gastrointestinal effects result from the medications' impact on gastric motility and are generally most pronounced during dose escalation, often improving with continued therapy as tolerance develops
