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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

Davis, L., & Thompson, P

A body might react adversely to B12 shots for a variety of reasons

The Take-Away Its important to note that while many people report positive effects from MIC/B-12 injections, the evidence supporting these benefits is limited

Also, although there was a trend toward lower muscle cell fats when combining the NNMT-inhibiting compound with exercise, the decline was not significant