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Glossary GLP-1 (Glucagon-Like Peptide-1) An incretin hormone produced in the gut that suppresses appetite, slows gastric emptying, and promotes insulin secretion

The interaction between SOD1 and Rac1 serves as a redox sensor for the regulation of NADPH oxidase (Harraz et al., 2008), and itself is redox-sensitive

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Similarly, in mesangial cells, GLP-1 receptor agonists have been shown to suppress either high-glucose-induced or AGEs-induced pro-fibrotic signalling pathways, including NF-B activation and TGF-1 expression, leading to reduced ECM deposition [60,61], and to suppress their proliferation via AMPK activation [62]

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