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However, magnetic resonance imaging (MRI) is the most specific and sensitive test for detecting bone disease and soft tissue involvement in MM ( 2.2 Mechanism of MM pathogenesis The pathogenesis of MM is a complex process leading to the replication of a malignant plasma cell clone that originates from the lymphoid B-cell lineage and develops after lineage commitment in the bone marrow (Kazandjian et al., 2014)

The C-terminal amide of native amylin is preserved, as is the N-terminal disulfide-bridged ring structure (Cys2Cys7), both of which are required for full amylin receptor efficacy

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