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This is hypothesized to preserve the bodys methyl pool, which is essential for DNA methylation and epigenetic regulation

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Plan your dose increase for a day when you can rest if needed

In contrast, there is some evidence of an enhancement of the maximum absorption via intrinsic factor, by up to a factor of 2, when the vitamin B12 is accompanied by food, but this is not consistently observed and probably only applies when the food quantity and vitamin B12 dose are sufficient to slow the passage of the vitamin B12 through the small intestine enough (about three hours or more) to allow each intrinsic factor receptor to absorb two molecules of vitamin B12 from the oral dose rather than one

This typically improves as treatment continues and should be discussed with your healthcare professional if persistent