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The Tebra survey questioned 640 GLP-1 users about microdosing the popular medications, asking if they did it and why
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For patients, GLP-1 & GIP agonists can stimulate insulinotropic responses similar to individuals with normal glycemic responses
However, the effectiveness can vary among individuals
The inositol requiring enzyme 1 alpha (IRE1) induced thioredoxin-interacting protein (TXNIP)/NLRP3 pathway activation and subsequent pyroptosis have been observed in both HG-exposed NRK-52E cells and diabetic rats (45)
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