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On rare occasions, affecting fewer than 2% of subjects, both peptides may also cause minor to moderate hepatobiliary conditions, such as gallstones and acute pancreatitis

OCTN2 ( SLC22A5 ) is not only a Na + -independent organic cation transporter but also a Na + -dependent and high-affinity carnitine transporter, which is widely distributed in various tissues such as kidney, intestine, placenta, breast, liver, heart, testis, skeletal muscle and bloodbrain barrier [161]

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This means that every patient will have different doses depending on their response and tolerance to the starting dose