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Regarding studies of potential treatments, N-acetylcysteine (NAC) is believed to exert therapeutic antioxidant effects as a substrate for glutathione synthesis

The peptide counteracted picrotoxin (non-competitive GABA receptor Cl channel blocker), isoniazid (inhibitor of glutamic acid decarboxylase and GABA synthesis), and bicuculline (GABA-A antagonist), all through dose-dependent protective effects without producing behavioral changes when administered alone

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Modular architecture: eccDNAs can carry complete gene coding sequences along with regulatory elements such as promoters and terminators, forming self-contained expression units (Guo et al., 2023

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