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Diabetes mellitus and oxidative stressa concise review

Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs

Interest in the therapeutic potential of inducing ferroptosis in cancer cells has led to a major research focus on inhibiting cellular antioxidant pathways that oppose ferroptosis