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This broad receptor engagement profile means that Melanotan II simultaneously activates melanogenic pathways (MC1R on melanocytes), appetite and energy homeostasis circuits (MC3R/MC4R in hypothalamus), and exocrine gland function pathways (MC5R), making it essential for researchers to design appropriate controls and selective antagonists into experimental protocols to attribute observed effects to specific receptor subtypes

[3] [2] In the United States, afamelanotide is indicated for increasing pain-free light exposure in adults with a history of reactions to light (phototoxicity) from erythropoietic protoporphyria

Fouladiun, M