tirzepatide discontinuation Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN - Horn - 2025 What really happens when patients

Jumping directly to a higher dose can cause severe nausea, vomiting, and discomfort

While water fasting can offer health benefits, including weight loss and cellular renewal, it also carries risks, especially with longer fasts

Tirzepatide (Mounjaro, Zepbound) Tirzepatide activates both GLP-1 and GIP receptors, providing stronger weight loss effects than semaglutide in head-to-head trials

There are discussions about using these drugs in overweight individuals (BMI 2730) to prevent progression to obesity or to treat weight-related conditions even at lower BMI, but currently insurance coverage is mainly for obesity or diabetes

Abbreviation definitions: BSO (buthionine sulfoximine, a known inhibitor of glutathione synthesis), WPI (whey protein isolate), and NAC (N-acetyl cysteine)