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To obtain a GLP-1RG s complex with good homogeneity and stability, we used the NanoBiT tethering strategy, in which the C terminus of GLP-1R was directly attached to LgBiT subunit followed by a TEV protease cleavage site and a double MBP tag
Long-term safety is uncertain
These findings suggest that suppression of the JAK2/STAT3 axis is a key mechanism by which EC attenuates inflammatory responses in macrophages (Yang et al., 2015)
However, patents validate novelty, not clinical efficacy
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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