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The glutathione cycle can complement the glutamate-glutamine shuttle and influence excitatory neurotransmission under conditions of glutamine restriction The glutamate-glutamine shuttle (Fig

The NAC group showed a significant increase in brain regions associated with Parkinsons compared to the control group, indicating a potential positive effect on the dopaminergic system

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In addition, glutathione, reduced as a result of interaction with a large number of oxidized organic metabolites, forms less toxic conjugated compounds, which are subsequently more easily metabolized and excreted as part of mercapturic acids

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