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Regardless, the clinical safety in humans is still largely unknown

Oral supplements, on the other hand, must pass through your digestive system, where they are partly metabolized before your body has access to orally given NAD+.

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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives