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No ZEPBOUND-treated patients in OSA studies developed neutralizing antibodies against tirzepatide activity on the GIP or GLP-1 receptors or against native GIP or native GLP-1

For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine

These cardiovascular benefits make these medications an attractive option for individuals with obesity and type 2 diabetes who are at risk for heart disease

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Semaglutide users report longer-lasting stomach discomfort