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This extensive modulation appears to reset gene expression patterns toward healthier states characteristic of younger tissue

BMJ 355:i4919 Mok J et al (2023) Safety and efficacy of liraglutide, 3.0 mg, once daily vs placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical trial

This early response is typically modest, serving as a sign that the compound is beginning to integrate with the body's internal processes

That reassurance does not survive scrutiny

The efficacy of metabolic therapies depends critically on HF phenotype, disease stage, and global metabolic network integrity (75)