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While other PD-associate genes, such as LRRK2 , SNCA , and GBA1 , regulate lysosomal functions, lipid metabolism, or protein aggregation, some have been shown to indirectly affect the electron transport chain

Methylmalonic Acid Homocysteine Notes on Clinical Trials of B12 Supplementation Although not addressed in the graphs, younger people who start out deficient tend to have more drastic, initial drops in MMA and homocysteine

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[77] For gut bacteria to produce vitamin B 12 , the animal must consume sufficient amounts of cobalt