As the membranes sustain oxidative damage, the mitochondria lose their ability to efficiently pump protons and generate ATP
O'Callaghan RM, Griffin EW, Kelly AM (2009)
Heres how they promote weight loss
The convergence of GLP-1 signaling with pathways of aginginsulin sensitivity, mitochondrial function, neuroinflammationsuggests these drugs may influence healthspan, not just body weight. (de Cabo & Mattson, 2019) For women entering their 50s and 60s, this convergence is especially powerful
Beyond triple agonism, researchers are exploring other combination approaches, including incretin plus amylin agonism or incretin plus FGF21 activation